Research Paper Volume 1, Issue 8 pp 733—739

Figure 3. Examples of EEE. (a) Depicts chromosomes of a newborn male with enhanced signal intensity at one p arm of chromosome 15 and at both chromatids of chromosome 16, (b). This is also the case at a single chromatid of 15q and on both chromatids of chromosome 7q in a 50-year-old male and, (c) at a single chromatid of chromosome 9p and at both arms of chromosome 10q in a male centenarian. (d) Schematic view of endoreduplication (ER), the result being a group of four homologous chromatids which emerged from one single chromatid. Note that the juxtapositions of the sister and descendant chromatids may be variable, since their three-dimensional packing is broken up by chromosome spreading. (e) Single chromosomes of a sporadic ER observed in a 40-year-old female with features of EEE. Since telomeric EEEs at 2p, 5q, 6q, and 10p are doublets and not quadruplets, EEE at these positions must have occurred one cell cycle prior to the ER event. In addition, there is a single telomeric EEE at 19q, which must have occurred during the S-phase directly preceding this ER.