Research Paper Volume 1, Issue 7 pp 622—636

Figure 9. Schematic diagram of genetic interactions involving AFO1 based on the results presented in this paper. Dashed arrows: genetic interactions for which a molecular mechanism has not been determined. Both Sfp1p and Rtg1,3p shuttle to the cytoplasm when Tor1p is inhibited by rapamycin. They are indicated in bold in the nucleus, where they are active. An activating influence of the TOR1 kinase complex on the transcription factor Rtg1/Rtg3 has been postulated by Dann [5]. Feedback inhibition of Tor1p by nuclear Sfp1p is indicated. The RAS/cAMP and SCH9 components are omitted for clarity. Their interaction with the TOR pathway is complex. M, mitochondrion; N, nucleus; P, peroxisome.