Figure 9. Schematic
diagram of genetic interactions involving AFO1 based on the
results presented in this paper. Dashed arrows: genetic interactions for
which a molecular mechanism has not been determined. Both Sfp1p and Rtg1,3p
shuttle to the cytoplasm when Tor1p is inhibited by rapamycin. They are
indicated in bold in the nucleus, where they are active. An activating
influence of the TOR1
kinase
complex on the transcription factor Rtg1/Rtg3 has been
postulated by Dann [5]. Feedback inhibition of Tor1p by nuclear Sfp1p is
indicated. The RAS/cAMP and SCH9 components are omitted for
clarity. Their interaction with the TOR pathway is complex. M,
mitochondrion; N, nucleus; P, peroxisome.
