Figure 3.
Different functions of Shp-2 in different cell compartments. Cytosolic
Shp-2 modulates different pathways by dephosphorylation of receptor
tyrosine kinases (RTK). It also decreases cytosolic ROS levels. Nuclear
Shp-2 inhibits ROS induced nuclear export of TERT and DNA-binding of STAT1
dimers by dephosphorylation. Prolactin induces the association of
Shp-2 and STAT5 and nuclear import of this complex. Shp-2/STAT5 complex
binds to DNA and induces transcription of milk genes. Functions of
mitochondrial Shp-2 remain unclear. A connection between mitochondrial Src,
Shp-2 and TERT may exist. Reduction of mitochondrial ROS formation seems to
depend on Shp-2.
