Figure 1.A hypothesis for the role of reduction of GSK3β in development of aging phenotype in the liver. GSK3β triggers degradation of cyclin
D3 in livers of young mice. The age-associated decline of growth hormone
and GSK3β leads to the stabilization of cyclin D3 and to
formation of transcriptional repressor C/EBPα-Brm and translational activator CUGBP1-eIF2 complexes. We suggest
that the appearance of these two comp-lexes in the liver might change
global transcription and translation leading to the development of aging
phenotype in the liver.
