Review Volume 1, Issue 6 pp 503—510

Figure 3. P66 ^Shc/ROS signaling determines fitness and aging associated dysfunctions. P66^Shc/ROS signals to specific functions that improve fitness whilst these same functions may increase disease risk chronically (such as obesity related disorders) and contribute to trigger p66^Shc-mediated cell death. Then, increased disease risk and cell loss rate contribute to aging dysfunctions.