Figure 2.Model of stem cell-mediated muscle regeneration. (modified from ref. 18).
Muscle injury involves the activation of satellite cells and the
recruitment of circulating stem cells, which when penetrating the muscle
compartment receive myogenic signals and may contribute to muscle
regeneration and repair. This process is enhanced by mIGF-1 expression. By
modulating the inflammatory response and reducing fibrosis, supplemental
mIGF-1 creates a qualitatively different environment for sustaining more
efficient muscle regeneration and repair.
