Research Paper Volume 1, Issue 5 pp 490—502
The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway
Figure 1. Sites of post-translational modifications on p53. Schematic representation of the 393 amino acid domain structure of human p53 showing the sites of post-translational modification including phosphorylation, acetylation, ubiquitination, methylation, neddylation, and sumoylation. Abbreviations: N-terminal transactivation domain (TAD); proline-rich domain (PRD); tetramerisation domain (TET); C-terminal regulatory domain (REG); arginine (R); lysine (K); serine (S); threonine (T).