Dual targeting of the antagonistic pathways mediated by Sirt1 and TXNIP as a putative approach to enhance the efficacy of anti-aging interventions

Shaker A. Mousa; Christine Gallati; Tessa Simone; Emmy Dier; Murat Yalcin; Evgeny Dyskin; Sudha Thangirala; Christine Hanko; Abdelhadi Rebbaa

doi:doi:10.18632/aging.100035

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Research Paper Volume 1, Issue 4 pp 412—424

Dual targeting of the antagonistic pathways mediated by Sirt1 and TXNIP as a putative approach to enhance the efficacy of anti-aging interventions

Figure 3. Effects of limited glucose availability, resveratrol and DHEA on expression of TXNIP and Sirt1 in normal cells. Aortic smooth muscle cells (panel A) and human embryonic stem cells (panel B) were treated as described in Figure 1 for cancer cells. Expression Sirt1 and TXNIP were analyzed by Western blot using specific antibodies. Antibody to GAPDH was used as loading control. (Glc: glucose., Resv: Resveratrol).