Research Paper Volume 1, Issue 4 pp 412—424
Dual targeting of the antagonistic pathways mediated by Sirt1 and TXNIP as a putative approach to enhance the efficacy of anti-aging interventions
Figure 1. Schematic representation highlighting the opposite effects of Sirt1 and TXNIP on oxidative stress and metabolism. Sirt1 has been shown to inhibit oxidative stress and improves glucose uptake as well as insulin secretion. In contrast, TXNIP was found to enhance cellular susceptibility to oxidative stress and inhibit glucose uptake and insulin secretion.