Supplementary Table 3. CPs with enrichment scores of less than -80 in A549 and HCC515 cell lines.

cp perturbagens with enrichment scores below -80 (opposing) in A549 cell line		cp perturbagens with enrichment scores below -80 in HCC515 cell line		"38 common elements and teir targets in ""A549"" and ""HCC515"":"	
cp	 score	cp	score	cp	target
WAY-213613	-99.66	roscovitine	-99.44	wortmannin	"PIK3CA, PIK3CG, PLK1, ATM, ATR, MTOR, PI4KA, PI4KB, PIK3CD, PIK3R1, PLK3, PRKDC"
ascorbic-acid	-99.58	aprepitant	-99.37	doxorubicin	TOP2A
bisacodyl	-99.49	CGP-60474	-99.34	TW-37	"BCL2, BCL2L1, MCL1"
QL-X-138	-99.44	BW-B70C	-99.29	camptothecin	"TOP1, HIF1A"
wortmannin	-99.29	BRD-K77681376	-98.81	topotecan	"TOP1, TOP1MT"
naproxol	-99.23	BVT-948	-98.74	lasalocid	
rimcazole	-99.05	L-BSO	-98.74	pidorubicine	TOP2A
benidipine	-98.48	thapsigargin	-98.73	BRD-K85853281	TOP2A
BMS-754807	-98.45	sirolimus	-98.66	methylene-blue	"ACHE, MAPT"
lofepramine	-98.14	topotecan	-98.61	BRD-K98824517	
urapidil	-98.01	CO-101244	-98.53	daunorubicin	"TOP2A, TOP2B"
famotidine	-97.87	pirarubicin	-98.48	alvocidib	"CDK2, CDK4, CDK1, CDK6, CDK7, CDK9, CDK5, CDK8, EGFR, PYGM, BCL2, BIRC5, CCNT1, MCL1, XIAP"
brazilin	-97.58	ZG-10	-98.33	rottlerin	"KCNH2, PRKCD, TGM2"
KN-93	-97.21	PLX-4720	-98.15	BRD-K53780220	
PI-103	-96.88	doxorubicin	-98.1	thapsigargin	ATP2A1
homosalate	-96.86	daunorubicin	-98.09	prednisolone	NR3C1
rhodomyrtoxin-b	-96.83	KIN001-055	-97.92	AT-7519	"CDK2, CDK5, CDK1, CDK4, CDK6, CDK9"
desoxycorticosterone	-96.15	palbociclib	-97.91	JNJ-26854165	"HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9, MDM2"
reversine	-96.11	progesterone	-97.84	NNC-05-2090	"SLC6A11, SLC6A12, SLC6A13"
maprotiline	-96.05	mycophenolate-mofetil	-97.78	ENMD-2076	"AURKA, FLT3, KDR, PDGFRA, SRC, CSF1R, EPHA1, FGFR1, FGFR2, FGFR3, FLT4, KIT, PTK2"
W-9	-96.04	guanabenz	-97.77	ISOX	HDAC6
doxorubicin	-96.02	A-443644	-97.71	IKK-2-inhibitor-V	IKBKB
vicriviroc	-95.96	bisbenzimide	-97.64	pepstatin	"CTSB, CTSD, CTSL, REN"
levocetirizine	-95.67	purvalanol-a	-97.61	fenretinide	"CYP2C8, CYP3A5, RARA, RARG"
ipratropium	-95.57	MY-5445	-97.52	BX-795	"PDPK1, CDK2, CHEK1, GSK3B, IKBKE, KDR, PDK1, TBK1"
mitoxantrone	-95.51	chelidonine	-97.48	etoposide	"TOP2A, CYP2E1, CYP3A5, TOP2B"
TW-37	-95	yohimbine	-97.43	remoxipride	"DRD2, DRD3, DRD4, HTR2A, SIGMAR1"
pazufloxacin	-94.88	letrozole	-97.17	ZG-10	MAPK8
lobendazole	-94.87	rottlerin	-97.04	bisindolylmaleimide-ix	"SIRT1, AKT1, GSK3B, LCK, LRRK2, MAPK1, MAPK11, MAPK12, MAPK14, MAPK8, PRKCA, ROCK1, RPS6KB1, SIRT2"
tibolone	-94.83	phorbol-12-myristate-13-acetate	-96.96	valdecoxib	"PTGS2, CA12, CYP2C19"
DY-131	-94.54	BRD-A07614565	-96.66	midostaurin	"FLT3, KIT, CCNB1, FLT1, KDR, PDGFRB, PRKCA, PRKCG, VEGFA"
buflomedil	-94.48	cefuroxime	-96.52	pirarubicin	TOP2A
noretynodrel	-94.46	heliomycin	-96.43	ER-27319	SYK
enalaprilat	-94.44	lestaurtinib	-96.41	SCH-79797	F2R
nicorandil	-94.34	SU-11274	-96.41	purvalanol-a	"CDK1, CDK2, CDK4, CDK5, CCND1, CCNE1, CSNK1G3, RPS6KA1, SRC"
LY-225910	-94.33	aminopurvalanol-a	-96.25	CCCP	
idarubicin	-94.18	bisindolylmaleimide-ix	-96.1	malonoben	EGFR
BI-2536	-94.14	BW-B70C	-96.06	bromocriptine	"DRD2, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD3, DRD4, DRD5, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, ADRA1A, ADRA1B, ADRA1D, HTR6, HTR7, PRL"
naltrindole	-94.11	dexketoprofen	-95.8		
HG-5-113-01	-94.07	PP-30	-95.78		
camptothecin	-94	ISOX	-95.77		
VU-0418947-2	-93.96	L-741742	-95.73		
oligomycin-a	-93.91	PIK-75	-95.65		
benzthiazide	-93.75	scriptaid	-95.62		
bifonazole	-93.65	lavendustin-c	-95.5		
tegaserod	-93.65	5-iodotubercidin	-95.48		
topotecan	-93.47	tetryzoline	-95.28		
17-hydroxyprogesterone-caproate	-93.11	rottlerin	-95.24		
flumetasone	-93.08	AG-14361	-95.21		
doxorubicin	-93.03	L-690488	-95.21		
danusertib	-92.92	cefaclor	-94.95		
PHA-793887	-92.84	lasalocid	-94.95		
BRD-K88761633	-92.79	daunorubicin	-94.89		
dofetilide	-92.68	PF-562271	-94.65		
BRD-K73610817	-92.66	AT-7519	-94.6		
lasalocid	-92.61	CG-930	-94.57		
pidorubicine	-92.57	AS-601245	-94.53		
parachlorophenol	-92.56	ryuvidine	-94.51		
tranilast	-92.56	pentylenetetrazol	-94.3		
fluticasone	-92.47	cymarin	-94.27		
clobetasol	-92.45	panobinostat	-94.26		
MBCQ	-92.29	BRD-K71427192	-94.2		
PIK-90	-92.14	"tropanyl-3,5-dimethylbenzoate"	-94.17		
BRD-K85853281	-92.13	BX-795	-94.13		
quinpirole	-92.05	protopine	-94.05		
methylene-blue	-91.84	PAC-1	-93.98		
physostigmine	-91.71	dichlorobenzamil	-93.93		
quinethazone	-91.71	dactinomycin	-93.76		
BRD-K14048378	-91.63	mosapride	-93.74		
picrotoxin	-91.4	GDC-0879	-93.74		
CHEMBL-374350	-91.33	pepstatin	-93.69		
BRD-K98824517	-91.26	bithionol	-93.62		
tremulacin	-91.24	SQ-29548	-93.58		
tyrphostin-AG-556	-91.18	nelfinavir	-93.55		
daunorubicin	-91.14	SCH-79797	-93.39		
tivozanib	-91.14	AG-592	-93.31		
triptolide	-91.12	gemcitabine	-93.26		
cytarabine	-90.99	propylpyrazole	-93.25		
CGP-53353	-90.79	fenretinide	-93.13		
alvocidib	-90.64	dorsomorphin	-92.83		
HG-5-88-01	-90.56	prednisolone	-92.69		
tyrphostin-AG-825	-90.53	mirtazapine	-92.67		
rottlerin	-90.42	bromocriptine	-92.38		
iopanoic-acid	-90.19	iodoacetic-acid	-92.34		
flavokavain-b	-90.19	gatifloxacin	-92.31		
canertinib	-90.16	tyrphostin-AG-1478	-92.13		
BRD-K53780220	-90.07	saracatinib	-92.03		
arctigenin	-90.07	BRD-K85853281	-91.81		
APHA-compound-8	-89.91	NNC-55-0396	-91.8		
niguldipine	-89.91	oxybuprocaine	-91.77		
digoxin	-89.78	tyrphostin-AG-555	-91.62		
SB-203186	-89.76	pinacidil	-91.61		
thapsigargin	-89.67	molindone	-91.41		
vecuronium	-89.53	chromomycin-a3	-91.36		
pentoxifylline	-89.48	GR-103691	-91.24		
JNJ-7706621	-89.4	BRD-K98824517	-91.23		
crizotinib	-89.39	entecavir	-91.02		
mepireserpate	-89.25	NNC-05-2090	-90.94		
VU-0420363-1	-89.1	midostaurin	-90.8		
molsidomine	-88.7	BRD-K36038115	-90.77		
prednisolone	-88.31	etoposide	-90.74		
AT-7519	-88.11	hippeastrine	-90.66		
JNJ-26854165	-88.04	digitoxigenin	-90.54		
NNC-05-2090	-87.92	GR-113808	-90.5		
XL-147	-87.83	diflorasone	-90.46		
everolimus	-87.82	NSC-663284	-90.43		
ENMD-2076	-87.78	PTB1	-90.3		
ISOX	-87.54	JNJ-26854165	-90.26		
terconazole	-87.42	THM-I-94	-90.19		
clobetasol	-87.38	solifenacin	-90.17		
daunorubicin	-87.26	terfenadine	-90.16		
CGK-733	-87.22	BRD-K19985802	-89.98		
IKK-2-inhibitor-V	-87.21	zibotentan	-89.94		
tetrindole	-87.19	pidorubicine	-89.77		
oxfendazole	-86.98	cilnidipine	-89.64		
M2-PK-activator	-86.97	malonoben	-89.6		
GBR-12935	-86.96	BRD-K53780220	-89.53		
floxuridine	-86.85	Merck60	-89.48		
nornicotine	-86.6	GW-405833	-89.23		
pepstatin	-86.52	GANT-61	-89.22		
metergoline	-86.36	IKK-2-inhibitor-V	-89.12		
fenretinide	-86.22	GDC-0941	-89.03		
L-168049	-86.19	PAC-1	-89		
simvastatin	-86.19	z-leu3-VS	-88.97		
troglitazone	-86.1	valdecoxib	-88.94		
mead-acid	-86.06	voriconazole	-88.85		
naproxen	-86	heraclenol	-88.61		
amsacrine	-85.96	SID-26681509	-88.42		
U-0126	-85.94	daunorubicin	-88.33		
fosinopril	-85.67	devazepide	-88.18		
ketoconazole	-85.52	hydrocortisone	-88.15		
motesanib	-85.49	CAY-10470	-88.13		
BX-795	-85.44	penfluridol	-87.96		
etoposide	-85.44	dubinidine	-87.94		
remoxipride	-85.25	thiazolopyrimidine	-87.9		
ZG-10	-85.07	daphnetin	-87.81		
prochlorperazine	-84.94	pyrazinamide	-87.72		
mycophenolic-acid	-84.82	SNS-314	-87.55		
fexofenadine	-84.71	alvocidib	-87.47		
proxyfan	-84.62	LFM-A13	-87.21		
SB-222200	-84.48	fluocinolone	-87.08		
KI-16425	-84.25	TWS-119	-87.08		
forskolin	-84.22	JW-7-24-1	-87.03		
bisindolylmaleimide-ix	-84.17	PP-1	-86.89		
valdecoxib	-83.89	donepezil	-86.87		
nefazodone	-83.73	amcinonide	-86.58		
perospirone	-83.71	iloprost	-86.5		
diclofenamide	-83.71	RO-3306	-86.37		
tozasertib	-83.69	ambelline	-86.34		
AMG-9810	-83.61	lypressin	-86.15		
coumestrol	-83.6	auranofin	-86.07		
CDC	-83.58	methylene-blue	-86.02		
norethindrone	-83.55	fludarabine	-86.01		
AM-580	-83.36	ouabain	-85.91		
SKF-96365	-83.36	GW-441756	-85.9		
hesperidin	-83.25	AM-404	-85.74		
midostaurin	-83.2	amiodarone	-85.72		
PRE-084	-83.02	apicidin	-85.71		
pirarubicin	-82.83	ER-27319	-85.7		
indirubin	-82.81	ingenol	-85.64		
clobenpropit	-82.73	LDN-193189	-85.5		
mibefradil	-82.73	CCCP	-85.37		
HA-1004	-82.7	levcromakalim	-85.18		
ER-27319	-82.61	remoxipride	-84.97		
ioxaglic-acid	-82.53	wortmannin	-84.95		
amitriptyline	-82.47	camptothecin	-84.93		
SCH-79797	-82.28	T-98475	-84.92		
idarubicin	-82.27	flunisolide	-84.91		
raltitrexed	-82.2	ENMD-2076	-84.89		
topotecan	-82.09	eriochrome-black-t	-84.78		
purvalanol-a	-81.99	puromycin	-84.68		
sorafenib	-81.95	granisetron	-84.57		
dioxybenzone	-81.83	TW-37	-84.26		
tolcapone	-81.75	CO-102862	-84.17		
CAY-10618	-81.66	selamectin	-84.1		
mepyramine	-81.62	erlotinib	-83.9		
butein	-81.47	PD-123319	-83.68		
KU-55933	-81.47	brucine	-83.66		
CCCP	-81.21	anagrelide	-83.66		
malonoben	-81.1	econazole	-83.62		
carbetocin	-80.97	doxorubicin	-83.58		
JNJ-38877605	-80.93	importazole	-83.51		
phenazone	-80.89	AM-281	-83.45		
biotin	-80.62	prednicarbate	-83.43		
antimycin-a	-80.56	nonoxynol-9	-83.34		
doxorubicin	-80.55	sulconazole	-83.32		
SSR-69071	-80.43	CGP-57380	-83.29		
fipronil	-80.42	flunarizine	-83.16		
wortmannin	-80.29	dihydrexidine	-82.92		
bromocriptine	-80.12	halcinonide	-82.9		
MST-312	-80.04	LY-165163	-82.79		
ZD-7114	-80.03	xylazine	-82.36		
		avrainvillamide-analog-2	-82.36		
		papaverine	-82.28		
		CGS-21680	-82.26		
		isoflupredone	-82.05		
		denbufylline	-82.04		
		tandutinib	-81.96		
		VAMA-37	-81.73		
		R-59022	-81.51		
		paroxetine	-81.1		
		angiogenesis-inhibitor	-80.75		
		dipropyl-dopamine	-80.5		
		tubastatin-a	-80.45		
		zardaverine	-80.4		
		GR-235	-80.05		
		RS-17053	-80.01