Research Paper Volume 16, Issue 8 pp 7060—7072

Keratin 6A (KRT6A) promotes radioresistance, invasion, and metastasis in lung cancer via p53 signaling pathway

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Figure 6. Effects of KRT6A knockdown on NSCLC cell viability and migratory capacity in vitro. (A) KRT6A expression in A549 cell transfected with negative control siRNA (si-NC) or siRNAs targeting KRT6A (si-KRT6A #1 and #2) for 48 h, n = 3 for each group. (B) Cell viability was assessed using a CCK-8 assay in A549 cell transfected with si-NC or si-KRT6A #1 and #2 for 48 h, n = 6 for each group. (C, D) Transwell invasion assay was performed to determine the invasion ability of si-KRT6A-transfected A549 cell for 48 h, n = 3 for each group. *P < 0:05, **P < 0:01 and ***P < 0:001 indicate significant differences.