Research Paper Volume 16, Issue 7 pp 6488—6509

Multidimensional data analysis revealed thyroiditis-associated TCF19 SNP rs2073724 as a highly ranked protective variant in thyroid cancer

class="figure-viewer-img"

Figure 2. TCF19[C] and TCF19[T] expression impacts thyroid cancer progression. (A) TCF19 expression was detected in KTC-1 and C643 cells transfected with pcDNA, TCF19[C] and TCF19[T] plasmids by Western blotting. (B) CCK8 assay was used to detect cell viability. (C) The EdU method was used to detect DNA synthesis. (D) Wound healing assay was used to detect cell migration. (E) Transwell assay was used to detect cell invasion and migration in the cells indicated above. (F) Tumor images in tumor-bearing mouse groups. (G) Mouse tumor weights in various groups. (H) Mouse tumor volumes were measured every four days. Data are shown as means ± S.D. *p < 0.05, **p < 0.01, ***p < 0.001, NS, not significant.