Research Paper Volume 16, Issue 3 pp 2161—2180
Integrative analysis of LAG3 immune signature and identification of a LAG3-related genes prognostic signature in kidney renal clear cell carcinoma
Figure 2. LAG3 and PDCD1 cell type distribution in KIRC by single-cell seq datasets and correlation of their expression trends. (A) Immunofluorescence staining of KIRC samples with DAPI (blue), LAG3 (red), CD45 (green), PAX8 (green), and the merged image (yellow) at 20× magnification, with a scale bar of 50 μm. (B) UMAP graph displays the distribution of cell types of LAG3 and PDCD1 expression in two single-cell seq datasets (KIRC_GSE111360 and KIRC_GSE121636). (C, D) LAG3 and PDCD1 expression levels across those two datasets in KIRC. (E) The pie chart shows the percentage of cell types in the two data sets. Bar graph showing the association between LAG3 (F) and PDCD1 (G) expression and OS, the correlation between PDCD1 expression and clinical stage (H) and grade (I) in multiple cancers.