Research Paper Volume 15, Issue 23 pp 14019—14038
Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by co-chaperone carboxyl-terminus of Hsp70 interacting protein in adipose-derived stem cells provide augmented cardioprotection in aging-hypertensive rats
Figure 8. The schematic diagram demonstrating the association of elevated levels of co-chaperone CHIP with better therapeutic benefits of rADSCs. Co-chaperone CHIP overexpression on rADSCs regulates the IGF1 secretion. Furthermore, transplantation of engineered rADSCs in aging-SHR model augments the cardioprotective effects and suppresses cardiac remodeling.