Research Paper Volume 15, Issue 21 pp 11860—11874
Lipid reprogramming induced by the NNMT-ABCA1 axis enhanced membrane fluidity to promote endometrial cancer progression
Figure 1. Bioinformatics analyses show that NNMT stimulates ABCA1 transcription, contributing to EC development. Results from the TCGA database (norm = 23, extreme = 543) are displayed. Variations in NNMT expression may be seen (A) throughout all FIGO stages (B) and pathological grades. (C) The quartile-based correlation between NNMT and OS is displayed (Low: 1st quartile distribution; Median: 2nd-3rd quartile distribution; High: 4th quartile distribution). ABCA1 expression varies among FIGO stages (D) and pathogenic subtypes (E). Shown below is the link between ABCA1 and OS (F). (G) The relationship between NNMT and ABCA1 expression in EC tissue.