Research Paper Volume 15, Issue 24 pp 14617—14650

Integrated analysis and validation of the TRIM28-H2AX-CDK4 diagnostic model assists to predict the progression of HCC

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Figure 3. TRIM28-related interaction and correlation gene enrichment analysis in HCC. (A, B) We obtained the TRIM28-binding top 50 proteins using the STRING tool (three different colors using Kmeans clustering), (A) the TRIM28-binding interaction genes from cBioPortal data, (B) the TRIM28-binding correlation genes from Gephia 2 data. The corresponding circos plot data in the detailed genes are displayed. (C) Venn diagrams was used to conduct the interaction analysis of the TRIM28-binding and correlated four genes (CCT2, CCT7, H2AX and SMARCA4).