Research Paper Volume 15, Issue 19 pp 10428—10452
Mitochondrial dysfunction following repeated administration of alprazolam causes attenuation of hippocampus-dependent memory consolidation in mice
Figure 1. Proteomic analysis of the hippocampus of mice following repeated administration of Alp (n = 6 per group). (A) The PCA analysis of the protein profiles. (B) Volcano map of the expression of all DEPs, which red indicating upregulation and green indicating downregulation. (C) Heat map demonstrating DEPs expression levels of Alp-treated animals versus controls, with red indicating upregulation and blue indicating downregulation. (D) The proportion of distribution of DEP in subcellular locations such as cytoplasm, nucleus, and mitochondrial. (E) GO analysis demonstrates the biological processes and protein functions in which mitochondrial subcellular localization proteins were involved. (F) The KEGG results of DEPs were identical to 15 pathways in the KEGG results of network pharmacology. The different colors of the columns represent p-value.