Research Paper Volume 15, Issue 19 pp 9913—9947

Figure 5. Effect of aging and reduced DNA double-strand break repair on micro- and macro-vascular properties. (A) Perfused microvascular density in mesenteric microcirculation. N = 10–15 per group. (B) Perfused microvascular density in mesenteric microcirculation. N = 14–18 per group. (C) Density of perfused capillaries between 5–9 μm in size from mesenteric microcirculation. N = 14–18 per group. (D) Perfused boundary region in capillaries between 5–9 μm in size in mesenteric microcirculation. N = 14–18 per group. (E) Perfused boundary region in all microvessels between 10–25 μm in size in mesenteric microcirculation. N = 14–18 per group. (F) Aortic stiffness assessed via pulse wave velocity. N = 11–17 per group. (G) Positive relation between PWV and percentage of aortic cells containing one or more 53BP1 foci. N = 5 per group. (H) Aortic elastin breaks. N = 5–6 per group. (I) Aortic mRNA expression of extracellular matrix and arterial stiffness-related genes. N = 7–9. Individual data points with black borders denote female mice. Individual data points matching group colors denote male mice. ^*p < 0.05, ^**p < 0.01, ^****p < 0.0001.