Research Paper Volume 15, Issue 12 pp 5611—5649

Identifying the role of NUDCD1 in human tumors from clinical and molecular mechanisms: a study based on comprehensive bioinformatics and experimental validation

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Figure 9. Enrichment analysis of NUDCD1-related partners. (A) NUDCD1-interacting proteins identified using STRING. (B) Wayne diagrams of intersection analyses of NUDCD1-correlated and inter-acting genes (data from GEPIA2 and STRING). (C) Corresponding heat maps of 4 NUDCD1-related genes in specific cancer types (data from GEPIA2). (D) Pathway and process enrichment analysis of 146 NUDCD1-related genes; a subset of enriched terms was selected and rendered as a network plot as indicated. (E) Enrichment scores for NUDCD1-related genes in the detailed cancers (data from GSCA). (F) Associations between GSVA score and activity of cancer related pathways (data from GSCA). (G) GSVA scores of NUDCD1-related genes in the detailed cancer types. (H) Survival differences between high and low GSVA score groups in multiple cancers (data from GSCA). (I) Survival differences between NUDCD1-related gene set mutant and WT (data from GSCA). (J) Survival differences between NUDCD1-related gene set CNV groups (amplification, deletion and WT) from GSCA database.